Here's everything you must know before Wednesday's opening bell

  1. Shire (SHPG) said it was willing to recommend a revised $64 billion offer from Takeda Pharmaceutical (TKPYY) . 
  2. Credit Suisse (CS - Get Report) posted its strongest quarterly earnings in three years as new cash poured into its wealth management division. 
  3. Texas Instruments' (TXN - Get Report) first quarter profit jumped 37%.
  4. Investors will analyze earnings from Facebook (FB - Get Report) , Qualcomm (QCOM - Get Report) and more.  
  5. U.S. stock futures pointed toward further losses and global stocks slumped. 
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