Markets closed lower Monday on poor manufacturing data from the U.S. and China while biotech stocks continued their dive - suffering their worst two-day fall since 2011. Questions have been raised over the prices some biotechs charge for drugs while concerns are rising around valuations in the sector. Fund mangers are also concerned at the prospect of recession in Russia after sanctions imposed for its incursion into Ukraine's Crimea. Jane Searle speaks with Jason Weisberg at the NYSE.

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