In yet another sign that video-game makers aren't safety stocks in a recession,

Take-Two Interactive

(TTWO) - Get Report

said Wednesday that it missed analysts' fourth-quarter targets and lowered its guidance for 2009.

The New York seller of titles like

Grand Theft Auto

posted an adjusted profit of $1.6 billion, or 2 cents a share, for the latest quarter. That's down from a nickel pro forma profit in the year-ago quarter and below analysts' estimates of 5 cents a share in adjusted earnings.

Sales for the fiscal fourth quarter ended Oct. 31 were $323.4 million, a 10% increase over the $292.6 million level a year ago. Analysts had expected revenue of $325.8 million, according to Thomson Reuters.

Looking ahead, the company expects to post adjusted fiscal 2009 earnings in the range of break-even to 20 cents a share on sales of about $1.17 billion. Wall Street estimates called for a pro forma profit of $1.26 a share on sales of $1.39 billion.

Take-Two shares fell 21% in after-hours trading Wednesday.

On the sunny side, Take-Two says it has secured a three-year extension of its agreement with Rockstar Group, the developers of the

Grand Theft Auto

franchise.

Take-Two is the second game giant to cut its financial forecast in as many weeks as the economy continues to falter. Last week, rival

Electronic Arts

(ERTS)

said its 2009 projections from October were too high, though the company did not provide any new targets.