Enslin, an executive board member and president of SAP's cloud business group, was with the company since 1992. He quit to pursue work elsewhere, according to statement from SAP.
"As I leave SAP for a new journey, I do so with unrivaled respect for the company and its amazing customers around the world," said Enslin in a statement.
Jennifer Morgan, currently an executive board member at the company, is slated to replace Enslin.
In a further shake up at the software giant, executive board member Adaire Fox-Martin is taking the reins as president of global customer operations.
During his decades-long career at SAP, Enslin was named to the executive board in 2014 as global customer operations president and then two years ago became president of cloud business, overseeing the buy of Qualtrics.
SAP specializes in a variety of software related to machine learning, Internet-linked devices and analytics that's used by 425,000 business and public customers, according to the company.
SAP had closed down 1.20% on Friday to $114.61