e-Sim (ESIM) , a maker of simulation technology for product development, customer support and Internet applications, was down 15% in midafternoon trading after hitting a 52-week low of $1.59. The company warned that it will report a larger-than-expected fourth-quarter operating loss of $2.9 million to $3.1 million and said it will cut its sales force in a bid to cut expenses by $2.5 million. The company also named Ken Dixon, head of its software tools division, as president. He succeeds Marc Belzberg, who will remain chairman and CEO. The shares are down from a 52-week high of $41.