- Japanese Ministry of Health, Labour and Welfare Grants SAKIGAKE designation for tepotinib, Merck ' s investigational highly selective c-Met receptor tyrosine kinase inhibitor
- First regulatory d esignation for tepotinib
- SAKIGAKE designation encompasses the possibility for a target review period of 6 months
Merck's oncology and immuno-oncology pipeline includes high-quality, selective small molecules, antibodies and antibody-drug conjugates with strong translational research data supporting each drug's clinical development. In addition to tepotinib, the oncology pipeline includes M7824, an investigational bifunctional immunotherapy, designed to simultaneously block two immunoinhibitory pathways (programmed death ligand-1 and transforming growth factor-ß), as well as a number of anti-DNA Damage Response molecules (including inhibitors of DNA-PK, ATR and ATM).*Tepotinib is the recommended International Nonproprietary Name (INN) for the c-Met kinase inhibitor (MSC 2156119J). Tepotinib is currently under clinical investigation and not approved for any use anywhere in the world. About Non-Small Cell Lung Cancer (NSCLC) Lung cancer (both small cell and non-small cell) has been the most common cancer in the world for several decades. 1 Globally, lung cancer is responsible for approximately 1 in every 5 deaths from cancer. 1 The five-year survival rate for people diagnosed with lung cancer that has spread (metastasized) to other areas of the body is 1%. 2 NSCLC is the most common type of lung cancer, accounting for 80 to 85% of all lung cancers. 2 MET Exon 14 skipping mutations occur in 2-3% of lung cancers. 3 About Tepotinib Tepotinib is an investigational, highly selective small-molecule inhibitor of the c-Met receptor tyrosine kinase. Alterations of the c-Met signaling pathway are found in various cancer types and correlate with aggressive tumor behavior and poor clinical prognosis. Tepotinib is being investigated in a Phase II study in non-small cell lung cancer. About Merck Merck is a leading science and technology company in healthcare, life science and performance materials. Around 50,000 employees work to further develop technologies that improve and enhance life - from biopharmaceutical therapies to treat cancer or multiple sclerosis, cutting-edge systems for scientific research and production, to liquid crystals for smartphones and LCD televisions. In 2017, Merck generated sales of € 15.3 billion in 66 countries.
Founded in 1668, Merck is the world's oldest pharmaceutical and chemical company. The founding family remains the majority owner of the publicly listed corporate group. Merck holds the global rights to the Merck name and brand. The only exceptions are the United States and Canada, where the company operates as EMD Serono, MilliporeSigma and EMD Performance Materials.All Merck Press Releases are distributed by e-mail at the same time they become available on the Merck Website. Please go to http://www.merckgroup.com/subscribe to register online, change your selection or discontinue this service. References
- International Agency for Research on Cancer (IARC). GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012; Lung Cancer. Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Last accessed: March 2018.
- Cancer.net. Lung cancer - non-small cell: statistics. Available from: http://www.cancer.net/cancer-types/lung-cancer-non-small-cell/statistics. Last accessed: March 2018.
- Reungwetwattana T, Liang Y, et al. The race to target MET exon 14 skipping alterations in non-small cell lung cancer: The Why, the How, the Who, the Unknown, and the Inevitable. Lung Cancer. 2017;103:27-37.