- NSI-566 was observed to extend hundreds of thousands of axons long distances from the graft site which appear to form synaptic connections with host neurons, including motor neuron populations;
- Host corticospinal axons regenerate into the NSI-566 graft;
- Grafting of NSI-566 led to a measurable improvement in forelimb function in injured animals.
Neuralstem is conducting a Phase 1 safety study for the treatment of paralysis from chronic motor stroke at the BaYi Brain Hospital in Beijing, China. In addition, NSI-566 was evaluated in a Phase 1 safety study to treat paralysis due to chronic spinal cord injury as well as Phase 1 and Phase 2a dose escalation, safety trials for ALS. Subjects from all three indications are currently in long-term observational follow-up periods to continue to monitor safety and possible therapeutic benefits.About Neuralstem Neuralstem is a clinical-stage biopharmaceutical company developing novel treatments for nervous system diseases of high unmet medical need. The Company has two lead development candidates:
- NSI-189, is a small molecule in clinical development for major depressive disorder (MDD) and in preclinical development for Angelman syndrome, irradiation-induced cognitive impairment, Type 1 and Type 2 diabetes, and stroke.
- NSI-566 is a stem cell therapy being tested for treatment of paralysis in ischemic stroke, Amyotrophic Lateral Sclerosis (ALS) and chronic spinal cord injury (cSCI).
Contact:Kimberly MinarovichArgot Partners (Investor Relations)firstname.lastname@example.org