- The Targeted RNAi Molecule (TRiM) Platform, which includes delivery targeted to the liver, tumors, and another tissue to be disclosed at the event
- ARO-AAT for liver disease associated with alpha-1 antitrypsin deficiency
- ARO-HBV for chronic hepatitis B infection
- ARO-APOC3 for cardiovascular diseases
- Updates on Arrowhead's clinical development timelines
Professor Stephen Locarnini, BSc, (Hons), PhD, MBBS, FRC (Path) is the Head of Research & Molecular Development at Victorian Infectious Diseases Reference Laboratory (VIDRL, originally Fairfield Hospital Laboratory). He is also Director of World Health Organization (WHO) Regional Reference Laboratory for Hepatitis B. His current major research interests include viral hepatitis, hepatitis vaccines, and antiviral chemotherapy with an emphasis on the basic virology of the various agents of hepatitis, the molecular pathogenesis of hepatitis, as well as prevention and public health control measures. The treatment of hepatitis B and C infections with antiviral agents represents a major focus. Professor Locarnini is the recipient of numerous awards including the Malaysian Liver Foundation Medal for work on Viral Hepatitis, the Bristol Myers Squibb Freedom to Discover Award and is the 2011 recipient of the European Association for the Study of the Liver (EASL) award for Scientific Recognition. He is author of over 200 peer-reviewed articles, 15 invited editorials and over 70 book chapters and reviews and every year for the past 5 years, has delivered a number of invited and plenary lectures at major international conferences. Professor Locarnini has recently co-founded the NGO, Coalition to Eradicate Viral Hepatitis in Asia-Pacific (CEVHAP).Ira Goldberg, MD is currently the Chief of the Division of Endocrinology, Diabetes and Metabolism at New York University Langone School of Medicine. Dr. Goldberg has published over 200 articles. These include written numerous book chapters, editorials, and reviews. He is an associate editor of both the Journal of Lipid Research and Journal of Clinical Lipidology. Dr. Goldberg's research has focused on abnormalities of lipoprotein metabolism, macrovascular disease in diabetes, and the role of triglycerides in atherosclerosis. He has received grant support in a number of investigational studies that involve atherogenicity of apolipoprotein B-containing lipoproteins, regulation of plasma triglyceride by lipase enzymes, diabetic macrovascular disease, and lipid uptake and toxicity in the heart. Among Dr. Goldberg's honors is a MERIT Award from the National Heart, Lung, and Blood Institute. He has previously served as chair of the NIH Metabolism and CADO (cellular aspects of diabetes and obesity) study sections.
About Arrowhead PharmaceuticalsArrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. For more information, please visit www.arrowheadpharma.com, or follow us on Twitter @ArrowheadPharma. To be added to the Company's email list and receive news directly, please visit http://ir.arrowheadpharma.com/alerts.cfm. Safe Harbor Statement under the Private Securities Litigation Reform Act: This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of various factors and uncertainties, including the safety and efficacy of our product candidates, the duration and impact of regulatory delays in our clinical programs, our ability to finance our operations, the future success of our scientific studies, our ability to successfully develop drug candidates, the timing for starting and completing clinical trials, rapid technological change in our markets, and the enforcement of our intellectual property rights. Our most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q discuss some of the important risk factors that may affect our business, results of operations and financial condition. We assume no obligation to update or revise forward-looking statements to reflect new events or circumstances. Source: Arrowhead Pharmaceuticals, Inc.