The untitled, six-episode series will premiere in 2018 and mark Letterman's first solo gig since retiring from the Late Show two years ago.
Each show will be pre-recorded and consist of Letterman engaging in long form discussions with a single guest, and feature the comedian touching on several topics on his own.
"I feel excited and lucky to be working on this project for Netflix. Here's what I have learned, if you retire to spend more time with your family, check with your family first. Thanks for watching, drive safely," Letterman said.
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