With a Twitter (TWTR) co-founder announcing a planned sale of 20% of his holdings this week, Twitter investors are pondering whether they should throw in the towel.

The shares have not participated with other social media giants, even though the service is famously used by President Trump to communicate directly with millions.

Management problems have been a recurring issue at the San Francisco-based company as well.

But when Jim Cramer asked panelists on this month's Trading Strategies roundtable "what's dangerous?", stock expert Stephen Guilfoyle brought up the urge to sell Twitter.

He said now is the wrong time for Twitter loyalists to give up on the stock. "They're getting into that wheelhouse where either they get taken over, or they find support," Guilfoyle said. "I don't know if it's really something you want to own long term, but I don't think if you're already longish base that you want to sell it here."

Click here to watch Cramer's entire Trading Strategies video. Or, you can read detailed advice on how to invest for the second quarter from Guilfoyle, Tchir, forex columnist Douglas Borthwick, and gold maven David Yoe Williams.

(Editor's Pick. This article originally ran at 9:31 a.m. ET on April 9.)

At the time of publication, Guilfoyle was long Twitter, although positions may change at any time.

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