LONDON, Dec. 1, 2016 /PRNewswire/ -- The global increase in the prevalence of cancer and the increasing recognition of the therapeutic and commercial opportunities offered by new oncology treatments has provided a major incentive for the pharmaceutical industry to pursue the development of new agents for the treatment of cancer. To tackle the ever rising global cancer burden, the cancer treatment is inclining towards the targeted drug therapy due to the numerous drawbacks associated with conventional chemotherapy. Targeted drug therapy includes targeting various signaling pathways associated to the tyrosine kinase receptors. Ample of studies have been performed which confirm their intrinsic involvement of tyrosine related pathways in development of the tumors. Until the late 1980s, it was thought of as impossible to target protein kinases by the tractable drugs, the reason lied in the presumed need to compete with adenosine triphosphate (ATP) as well as concerns regarding selectivity of the potential drugs. Since then, considerable progress has been made, and the past few years have seen a number of kinase inhibitors which have entered the market. Till now, 518 protein kinases have been encoded from the human genome; we call it as Human Kinome. From the encoded human genome, 90 kinases belong to the group of tyrosine kinases. The tyrosine kinase group consists of approximately 30 families, for example the VEGFR family and the fibroblast growth factor receptor (FGFR) family. Six other groups have been identified whose kinases primarily phosphorylate serine and threonine residues. Tyrosine kinases play the most critical part in the modulation of growth factor signaling. Activated forms of these enzymes can cause increases in tumor cell proliferation and growth, induce antiapoptotic effects, and promote angiogenesis and metastasis. In addition to activation by growth factors, protein kinase activation by somatic mutation is a common mechanism of tumor genesis. Because all of these effects are initiated by receptor tyrosine kinase activation, they are key targets for inhibitors.