NEW YORK, Nov. 23, 2016 /PRNewswire/ -- A new study suggests that individuals using certain heartburn medications, including proton pump inhibitors like Nexium, Prilosec and Prevacid, may be more likely to develop kidney stones. The authors of the study, which was presented this month the American Society of Nephrology's annual Kidney Week event in Chicago, Illinois, analyzed data on more than 187,330 individuals without a prior history of kidney stones. During a follow-up of up to 12 years for proton pump inhibitors and 26 years for H2 blockers, 3,245 subjects experienced symptomatic kidney stones. After adjusting for certain risk factors, the research team concluded that proton pump inhibitors were associated with a 12% higher risk of developing a kidney stone, while H2 blockers were associated with a 13% higher risk.
Analysis of a subgroup of patients also linked proton pump inhibitor use to lower urinary excretion of calcium, oxalate, citrate, and magnesium, all of which are components of kidney stones. "This is only the latest research to link drugs like Nexium to serious kidney complications. Other recent studies have suggested that the long-term use of proton pump inhibitors may be associated with an increased risk of chronic kidney disease, kidney failure and acute kidney injury," says Sandy A. Liebhard, a partner at Bernstein Liebhard LLP, a nationwide law firm representing victims of defective drugs and medical devices. The Firm is actively filing proton pump inhibitor lawsuits on behalf of patients who allegedly suffered kidney complications due to their use of Nexium and similar heartburn drugs. Proton Pump Inhibitor Side EffectsProton pump inhibitors are approved for the short-term treatment of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. Prescription medications in this class include:
Dexilent, Kapidex (dexlansoprazole)
A number of these drugs are also available in over-the-counter versions.