Direct Injection Of CAR-Engineered CD19.taNK Cells Demonstrating Potential

NantKwest Inc. (Nasdaq:NK), a pioneering, next-generation, clinical-stage immunotherapy company focused on harnessing the unique power of our immune system using natural killer (NK) cells to treat cancer, infectious diseases and inflammatory diseases, today announced that the Company's abstract reviewing data on the company's CD19.taNK program has been accepted for an oral presentation at the upcoming 58 th Annual Meeting of the American Society of Hematology (ASH) in San Diego, CA, December 3-6, 2016.

"NantKwest's transition from preclinical to clinical studies continues to make significant progress," said Patrick Soon-Shiong, MD, Chairman and CEO of NantKwest. "In these preclinical studies, aNK cells expressing a CD19-CAR (CD19.taNK) demonstrated strong killing of CD19-positive cancer cells. In addition, direct tumor injections of CD19.taNK into a fully immunocompetent mouse model induces tumor clearance and protection from tumor re-challenge, suggesting the induction of a memory ('vaccine') protective effect after the injection of the CD19.taNK cell."

Presentation Summary

Intra-Tumor Injection of CAR-Engineered NK Cells Induces Tumor Regression and Protection Against Tumor Re-Challenge

This poster will review the potential use of CD19.taNK cells to effectively kill cancer cells. In vivo preclinical studies of direct tumor injection of CD19.taNK cells induces significant tumor regression and significantly improved survival, with 75% of the mice showing complete tumor regression at day 32 (p<0.05). Upon re-challenge with A20 lymphoma cells, >80% mice remained free of tumor after 14 days.

NantKwest

NantKwest (Nasdaq:NK) is a pioneering, next-generation, clinical-stage immunotherapy company focused on harnessing the unique power of our immune system using natural killer (NK) cells to treat cancer, infectious diseases and inflammatory diseases. NK cells are the body's first line of defense due to the innate ability of NK cells to rapidly identify and destroy cells under stress, such as cancer or virally infected cells.

If you liked this article you might like

Juno, bluebird In Focus as Targets Following Gilead-Kite Aquisition

Biotech Movers: Cerus, Alexion, NantKwest

Biotech Movers: Valeant Shares Jump After Raising Adjusted Ebitda Outlook

Discovery's David Zaslav Shows It's Good to Be a Media CEO

Biotech Premarket Movers: Sage Therapeutics, Depomed, NantKwest