In a second in vitro study (Abstract #PO845), researchers evaluated two different classes of membranes, a high-flux dialyzer and a high-cut off (HCO) dialyzer, to assess their ability to clear four mid-sized molecules that may affect a range of biological functions, including inflammation and cardiovascular function. The molecules studied are of potential interest for the treatment of myeloma kidney, a complication associated with multiple myeloma, a blood cancer; sepsis, a potentially fatal inflammatory response to infection; and rhabdomyolysis, a breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood that often causes kidney damage.After simulating treatment with each dialyzer, researchers concluded that the HCO membrane provided a more efficient removal of the molecules studied, and that a high-flux membrane did not offer the rate of removal that is required in acute care treatment. ''While our findings conclude that targeting these molecules is possible, further research will help us understand the clinical impact of removing these molecules from the blood,'' said Markus Storr, senior R&D manager, Baxter, and one of the authors of the studies. In total, Baxter presented 24 abstracts at ASN to support the latest scientific exchange for home, in-center and acute dialysis. For 60 years, Baxter has been at the forefront of innovation to advance the treatment of kidney disease. In 1956, Baxter collaborated with Dr. Willem Kolff, inventor of the artificial kidney, to design the world's first complete dialysis delivery system, which included the first commercially available disposable dialyzer. Today, Baxter builds on this rich heritage of innovation by developing next generation products for hemodialysis, peritoneal dialysis and continuous renal replacement therapy. Learn more about Baxter's legacy of advancing essential healthcare. About Baxter International Inc. Baxter provides a broad portfolio of essential renal and hospital products, including home, acute and in-center dialysis; sterile IV solutions; infusion systems and devices; parenteral nutrition; biosurgery products and anesthetics; and pharmacy automation, software and services. The company's global footprint and the critical nature of its products and services play a key role in expanding access to healthcare in emerging and developed countries. Baxter's employees worldwide are building upon the company's rich heritage of medical breakthroughs to advance the next generation of healthcare innovations that enable patient care.
Baxter is a registered trademark of Baxter International Inc.__________________________________ 1 Akchurin OM, Kaskel F. Update on Inflammation in Chronic Kidney Disease. Blood Purification 2015; 39:84-92.