Baxter International Inc. (NYSE: BAX), a global leader in renal and critical care innovation, today announced research on the role of extracorporeal blood purification (EBP) in the removal of molecules linked to inflammation that was presented at the American Society of Nephrology's (ASN) annual Kidney Week in Chicago. ''Baxter continues to build on its commitment to contribute meaningful research to advance acute and chronic blood therapies,'' said Dheerendra Kommala, M.D., vice president, Medical Affairs, Baxter. ''This exploratory research adds to the body of knowledge in an important area that is not fully understood - the treatment of inflammation-related conditions in chronic kidney disease and critically ill ICU patients.'' EBP is a method of blood purification that takes place outside the body. Blood passes through a membrane within the extracorporeal circuit, which filters harmful molecules or waste products in the blood, returning it to a normal state. This cleaned blood is then returned to the body. This type of therapy is most often used for patients with acute kidney injury, who are unable to clear toxins from their blood due to a sudden loss of kidney function. Baxter researchers looked at two new areas where EBP may play an expanded role in the future. In one in vitro study (Abstract #PO942), researchers compared different membranes to assess their ability to remove cytokines including IL-6, a molecule that stimulates the body's inflammatory and auto-immune response during trauma or illness. Chronic inflammation can be a concern for end-stage renal disease patients and can lead to complications such as cardiovascular disease. 1 In ICU patients, severe inflammation can lead to organ failure. The study reported that membranes included in the analysis can remove IL-6 and certain cell activating molecules, with more porous mid-cut off and high-cut off membranes able to remove these molecules at a higher rate.