CHESTERFIELD, United Kingdom, Nov. 17, 2016 /PRNewswire/ -- Mallinckrodt plc (NYSE: MNK), a leading global specialty pharmaceutical company, today presented results of a retrospective, claims-based analysis that indicated the use of H.P. Acthar ® Gel (repository corticotropin injection) may be associated with reductions in corticosteroid (CS) requirements among patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and dermatomyositis and polymyositis (DM/PM). The data was unveiled today at the 2016 American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting Nov. 11-16 in Washington, D.C.
H.P. Acthar Gel is approved by the U.S. Food and Drug Administration (FDA) for use during an exacerbation or as maintenance therapy in select DM/PM or SLE patients. It is also approved as adjunctive therapy for short term administration in RA patients to tide patients over an acute episode or exacerbation. The Mallinckrodt-sponsored analysis, titled " Effects of Repository Corticotropin Injection on Medication Use in Patients with Rheumatologic Conditions: A Claims Data Study" (abstract #2236), identified patients in the Symphony Health Solutions Patient Transactional Dataset from 2008 to 2015. The study examined the demographics of those who used H.P. Acthar Gel and trends in other medications' use after H.P. Acthar Gel initiation (concomitant use), specifically prednisone - a corticosteroid - as well as other CS, biologics, non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying anti-rheumatic drugs (DMARDs), all of which were reported. Patients were followed for concomitant medication use from two years prior to and one year after H.P. Acthar Gel initiation. Paired two-tailed t-tests (a statistical test of differences) were used to calculate the p values for the use of each drug class before/after H.P. Acthar Gel initiation.