The successful completion of this Phase 1 pharmacokinetic (PK) trial in patients with severe renal impairment clears the path for the Company to further expand its previously announced Renal and Orphan programsCALGARY, Nov. 17, 2016 /PRNewswire/ - Resverlogix Corp. ("Resverlogix" or the "Company") (TSX:RVX) today announced the collection of successful data from the New Zealand based Phase 1 PK study with lead drug candidate apabetalone in patients with severe renal impairment. Resverlogix was able to confirm its primary objective of the Phase 1 study by demonstrating that apabetalone treated patients with severe renal impairment have the same favorable PK traits and safety profile as has been observed in previous apabetalone trials. These results will allow the Company to proceed with more advanced renal impairment and dialysis trials. The study also explored acute changes in biomarkers relevant to Bromodomain and Extra-Terminal (BET) inhibition in subjects with severe renal impairment, the data for which is still under analysis. Two cohorts, each comprised of eight subjects, were evaluated in the study. Cohort one included subjects with end-stage renal disease (ESRD) not on dialysis, with an estimated glomerular filtration rate (eGFR) of less than 30 mL/min/1.73m 2 (normal eGFR range > 90 mL/min/1.73m 2) while cohort two included healthy individuals whose age, weight and gender were matched to the renal impaired subjects. The Company's Phase 3 BETonMACE trial, designed for high-risk cardiovascular disease patients with type 2 diabetes and low high-density lipoprotein (HDL), continues enrollment as planned. The Company now plans to initiate a Phase 2 Renal Impairment trial that is expected to commence in early 2017 based on the PK data confirmed in the Phase 1 trial. This new trial has been initiated and designed in accordance with the Company's strategy to expand into new indications such as renal (chronic kidney disease) and orphan diseases with its lead candidate, apabetalone. With continued success, this trial has the potential to create incremental value for apabetalone in new high-risk patient segments which have shorter development paths to product registration and market adoption.