The article is titled "Elucidating the interplay between IgG-Fc valency and Fc¿R activation for the design of immune complex inhibitors" and is available at http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aaf9418.About M230, Selective Immunomodulator of Fc Receptors (SIF3)Antigen-autoantibody immune complexes (ICs) are a common pathogenic hallmark of many autoimmune diseases. The multiple Fc domains of ICs aggregate Fc¿ receptors (Fc¿Rs), triggering cellular activation processes that play critical roles in inflammation. The rational engineering of therapeutics that broadly antagonize Fc¿Rs has been hampered by a limited understanding of the molecular determinants directing Fc¿R activation. Through the engineering and characterization of oligomeric Fc structures, Momenta was able to provide novel insights on Fc¿R modulation and has generated a unique recombinant Fc oligomer therapeutic candidate, referred to as M230, with optimal physiochemical and biological properties. Preclinical studies with M230 have shown enhanced potency over intravenous immunoglobulin in animal models of autoimmune disease. M230 is currently in preclinical development and has the potential to be developed as a first-in-class therapeutic for patients with IC-driven disease. About MomentaMomenta Pharmaceuticals is a biotechnology company specializing in the detailed structural and functional analysis of complex drugs and is headquartered in Cambridge, MA. Momenta is applying its technology to the development of generic versions of complex drugs, biosimilar and potentially interchangeable biologics, and to the discovery and development of novel therapeutics for autoimmune indications. To receive additional information about Momenta, please visit the website at www.momentapharma.com, which does not form a part of this press release. The company's logo, trademarks, and service marks are the property of Momenta Pharmaceuticals, Inc. All other trade names, trademarks, or service marks are property of their respective owners. Cautionary Note Regarding Forward-Looking StatementsStatements in this press release regarding management's expectations, beliefs, intentions, goals, strategies, plans or prospects, including statements about the significance and application of research findings, future clinical studies and clinical study results for M230 are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can sometimes be identified by words such as "anticipate," "believe," "continue," "could," "hope," "target," "project," "goal," "objective," "plan," "potential," "predict," "might," "estimate," "expect," "intend," "may," "seek", "should," "target," "will," "would," "look forward" and other similar words or expressions, or the negative of these words or similar words or expressions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. Important factors include Momenta's ability to fund and successfully conduct clinical trials of its M230 product candidate, either independently or in collaboration with a collaborative partner; the possibility of unfavorable or disappointing clinical trial results, including whether the properties of our multivalent Fc products for blocking IC-mediated damage are optimized for potential use in humans; Momenta's ability to successfully partner the M230 program; and the factors listed under "Risk Factors" in Momenta's Quarterly Report on Form 10-Q for the quarter ended September 30, 2016 filed with the Securities and Exchange Commission, as well as other documents that may be filed by Momenta from time to time with the SEC. Momenta is providing the information in this press release as of the date hereof and assumes no obligations to update the information included in this press release or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
Investor Relations:Sarah CarmodyMomenta Pharmaceuticals1-617-395-5189IR@momentapharma.comMedia Relations:Karen SharmaMacDougall Biomedical Communications1-781-235-3060 Momenta@macbiocom.com