LEXINGTON, Mass. and GRONINGEN, Netherlands, Nov. 16, 2016 /PRNewswire/ -- CSA Medical, Inc., a company focused on developing spray cryotherapy devices that selectively freeze and ablate unwanted tissue inside the body, today announced the company has begun Phase B of its clinical study to evaluate the safety and feasibility of treating Chronic Bronchitis patients with the RejuvenAir ® System. November 16 is World COPD Day. Started in 2002, World COPD Day was designed to raise awareness of COPD, and promote early diagnosis of the disease. Chronic bronchitis is a subset of COPD, and currently has limited treatment options. Three of the patients that were previously treated in phase A of this first feasibility study have undergone their second treatment, marking the start of Phase B of the study. Dr. Dirk-Jan Slebos, M.D., PhD in the Department of Pulmonary Diseases at University Medical Center Groningen, The Netherlands performed these treatments. All patients enrolled in Phase A of the study, which consisted of treating the right lower lobe and right main stem of the right lung, will be scheduled for their second treatment, which will treat the left lower lobe and left main stem of the left lung. A third treatment will follow 30-45 days later, which will treat the upper lobes of both lungs and trachea, completing the therapy. "The initiation of Phase B of this study is a major step forward as these patients will now be treated with the full therapy. We will continue to monitor improvements in the patients' SGRQ scores to assess the potential for a positive impact to the lives of chronic bronchitis patients," said Ellen Sheets, MD, CEO CSA Medical. The RejuvenAir ® System is designed to spray liquid nitrogen at -196 oC in a circumferential pattern within the airway. It is anticipated that the rapid freezing of the epithelial layer of the airway walls will destroy the mucus-producing goblet cells while preserving the extracellular matrix, thereby enabling the regrowth of healthy cells. The Safety and Feasibility Study of RejuvenAir for Treating Chronic Bronchitis Patients (NCT02483637) is a prospective, open label, single arm, two phase study with sequential accrual of patients with known chronic bronchitis. Phase A enrolled 11 patients and treated a single lobe to assess safety, feasibility and histologic/immunologic response. Phase B of the study began after review and approval of the Phase A data by the Data Safety Monitoring Board. In Phase B of the study, Phase A patients will have their remaining lobes treated. In Phase B, up to 24 additional patients will be enrolled. Once all patients have received complete treatment of both lungs they will be periodically followed for safety and physiologic response of their underlying chronic bronchitis to this novel treatment.