Cytori Strengthens Global Intellectual Property Portfolio With Key Patents

Cytori Therapeutics, Inc. (NASDAQ: CYTX) ("Cytori" or the "Company") announced today the issuance of a number of key patents that strengthen its intellectual property portfolio in the U.S. and Europe. Cytori now has over 90 global patents issued and another 55 patent applications pending around the globe. Several of Cytori's recently-issued patents contain claims providing protections for Cytori's program in the use of Cytori Cell Therapy™ for treating scleroderma. Cytori recently completed enrollment in its STAR approval trial in the US for this indication.

On November 1, 2016, US Patent No. 9480718 was issued. This patent contains claims applying to the use of adipose derived cells to treat peripheral vascular diseases ("PVD"), which are blood circulation disorders that affect the blood carrying vessels of the body that can narrow, experience spasm or become blocked. PVD is often a contributory process in scleroderma. This patent has term at least through 2022 and claims the use of Cytori Cell Therapy™ for PVD, including but not limited to PVD associated with scleroderma.

On November 8, 2016, US Patent No. 9486484 was issued. This patent provides protections around the use of adipose-derived cells for the treatment of edema. Edema, also known as 'swelling', is often accompanied by increased blood flow and is a very common secondary clinical manifestation of numerous inflammatory and immune-related conditions. Specifically, edema contributes directly to the diminished hand dysfunction found often in the acute phases of scleroderma. The '484 patent term lasts through at least 2029.

Other recently issued patents strengthen Cytori's osteoarthritis program. Last month, US Patent No. 9463203 was issued. The '203 patent protects the use of adipose-derived cells for treating cartilage defects, including but not limited to osteoarthritic defects, defects in the articular cartilage and defects in meniscus. Earlier this year, Cytori completed the ACT-OA clinical trial, a phase IIb trial assessing the use of adipose-derived cells for the treatment of osteoarthritis of the knee. The '203 patent term lasts through at least 2022.

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