vTv Therapeutics Inc. (vTv, Nasdaq:VTVT), a clinical-stage biopharmaceutical company engaged in the discovery and development of new orally administered small molecule drug candidates to fill significant unmet medical needs, today announced that Dr. Bobby Thomas, Associate Professor at Medical College of Georgia, Georgia Regents University at Augusta, will present a poster at the Society for Neuroscience 2016 meeting in San Diego, featuring new pre-clinical data on a vTv small molecule drug candidate against Parkinson's disease (PD). vTv has identified novel non-electrophilic Nrf2/Bach1 modulators that can activate nuclear factor-E2 related factor ("Nrf2") and inhibit Bach1 (the Antioxidant Response Element ("ARE") transcriptional repressor) leading to potent activation of the Nrf2 pathway. The results from the laboratory of Dr. Thomas suggest (1) Bach1 may be a promising novel target for drug development against Parkinson's disease, and (2) vTv's compound, HPPE, may protect against nigrostriatal dopaminergic neurodegeneration by virtue of its ability to activate neuroprotective Nrf2/ARE genetic response in a preclinical mouse model of Parkinson's disease. Based on recent findings, aberrant oxidative stress and inflammation play a key role in the pathogenesis of PD and preclinical studies suggest that activating the Nrf2/Bach1 pathway could have disease modifying effects on PD. Current pharmacological approaches targeting the Nrf2 pathway presents safety and tolerability issues as these pharmacophores contain reactive electrophilic groups. Parkinson's disease is a progressive and debilitating neurodegenerative movement disorder characterized by marked nigrostriatal dopaminergic cell loss in the brain. No preventive therapy or cure is yet available for PD. Dr. Thomas will be available to discuss the findings at the Society for Neuroscience 2016 meeting on Wednesday Nov. 16 from 1-5:00 pm at poster #19, Hall D-H at San Diego Convention Center. About vTv Therapeutics vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of orally administered small molecule drug candidates to fill significant unmet medical needs. vTv has a pipeline of clinical drug candidates led by programs for the treatment of Alzheimer's disease and type 2 diabetes as well as treatment of inflammatory disorders and the prevention of muscle weakness.