SAN FRANCISCO, Nov. 16, 2016 /PRNewswire/ -- Glycomine, Inc. a biotechnology company developing a new generation of replacement therapies for rare diseases, today announced that it has raised $12 million in a Series A financing led by Sanderling Ventures and supported by Chiesi Ventures as well as existing high net worth individuals and patients. Glycomine will use the proceeds from this financing to complete IND enabling pre-clinical studies and initiate clinical studies of its substrate replacement therapy in patients with Congenital Disorder of Glycosylation Type Ia (CDG-Ia), and to accelerate discovery efforts towards an enzyme replacement therapy for N-glycanase deficiency (Ngly1). "Glycomine's approach to a new generation of replacement therapies focuses on intracellular delivery and targeting of treatments to clinically relevant organs," said Agnes Rafalko, PhD, Glycomine's Chief Executive Officer. "We are very grateful for the funding and support we have received from our investors, patients' families, and doctors as we embark on the development of the first-ever replacement therapy for CDG-Ia." The therapy has the potential to significantly improve both patients' quality of life and lifespan. "CDG-Ia is a debilitating disorder with no treatment and Glycomine's approach to therapy is our only hope for these patients," said Prof. Jaak Jaeken of University of Leuven, Belgium, the mastermind behind the discovery of Congenital Disorders of Glycosylation. Replacement therapies continue to play an important role in orphan diseases. "One of the advantages of substrate or enzyme replacement therapies is having the ability to adjust the therapeutic dose according to patients needs and disease severity," said Gregory Enns, MD, of Stanford Medicine who is also a member of the company's Clinical Advisory Board.