Bristol-Myers Squibb Showcases Rheumatoid Arthritis And Immunoscience Commitment With Depth Of Research At 2016 American College Of Rheumatology And Association Of Rheumatology Health Professionals Annual Meeting

Bristol-Myers Squibb Company (NYSE:BMY) today unveiled rheumatoid arthritis (RA) and autoimmune disease data being presented at the 2016 Annual Meeting of the American College of Rheumatology (ACR) and the Association of Rheumatology Health Professionals (ARHP) in Washington, D.C. The Company will present 23 abstracts that exemplify Bristol-Myers Squibb's leadership in autoimmune disease. This includes real-world data analyses examining the role of poor prognostic factors, with a focus on anti-cyclic citrullinated protein antibodies (anti-CCP, also known as ACPA), in patients with moderate to severe RA. Bristol-Myers Squibb's ACPA-related research has helped further the understanding of ACPA as a key prognostic factor related to rapidly progressive RA.

Among the data being presented are two real-world data analyses from the ongoing Corrona ® RA registry - the largest RA cohort prospectively followed in North America. One analysis showed a significant relationship between poor prognostic factors for RA and work status over 12 months. Patients with the worst prognostic factors were less likely to have a part-time or full-time job compared with those having a better RA prognosis. Despite the association between poor prognostic factors and work limitations, the other analysis found no significant association between the presence of 0-1, 2, or 3+ poor prognostic factors for RA and treatment initiation with a biologic therapy over 12 months, suggesting that poor prognostic status does not currently influence RA treatment decisions.

"These data analyses represent clinically meaningful RA research that enrich our understanding of the disease and suggest an important role for the evaluation of RA patients' status with regard to poor prognostic factors. Patients with a greater number of poor prognostic factors despite treatment had smaller reductions in clinical disease activity index (CDAI) and were less likely to achieve low disease activity (LDA)/remission following their treatment," said Joel M. Kremer, M.D., Founder and Chief Medical Officer of the Corrona RA registry, as well as a practicing rheumatologist at Center for Rheumatology, LLP in Albany, NY and Pfaff Family Professor of Medicine at the Albany Medical College. "Findings like these demonstrate how poor prognostic factors may inform the way the rheumatology community approaches the disease."

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