- Treatment with an endoglin antibody significantly decreased the percentage of the liver fibrosis area induced by carbon tetrachloride. A group of mice treated with endoglin antibody demonstrated lower collagen deposition with less frequent formation of bridging fibrosis than the isotype-matched and disease control groups.
- Treatment with endoglin antibodies significantly reduced the non-alcoholic fatty liver disease (NAFLD) activity score (NAS) in a model of non-alcoholic steatohepatitis (NASH), known as the STAM TM model. Endoglin antibodies demonstrated hepatoprotective, anti-inflammatory and anti-fibrotic effects. In addition, an endoglin antibody that competitively inhibited bone morphogenic protein (BMP) binding to endoglin more effectively reduced the NAS, suggesting that inhibition of BMP function is an important mechanism of action of endoglin antibodies in models of fibrosis.
SAN DIEGO, Nov. 13, 2016 (GLOBE NEWSWIRE) -- TRACON Pharmaceuticals (NASDAQ:TCON), a clinical stage biopharmaceutical company focused on the development and commercialization of novel targeted therapeutics for cancer, wet age-related macular degeneration and fibrotic diseases, today presented data at the American Association for the Study of Liver Diseases (AASLD) Annual Meeting, taking place November 11-15 in Boston, MA. Preclinical data were presented from two separate liver fibrosis models in a poster presentation entitled, "Endoglin Antibody Reduces the NAFLD Activity Score in the STAM Model of NASH and Reduces Liver Fibrosis Following Carbon Tetrachloride Treatment." Highlights include: