BOSTON, Nov. 11, 2016 /PRNewswire/ -- Two injections of RG-101, in combination with a four-week course of direct-acting antiviral (DAA) therapy, has been shown to clear hepatitis C in patients at both 12 and 24 weeks after treatment in the majority of patients, according to research presented this week at The Liver Meeting® — held by the American Association for the Study of Liver Diseases. Hepatitis C (HCV) is a liver disease commonly spread through blood. In recent years, DAA treatment has changed the prognosis of this disease from chronic to curable, and the current standard of care for HCV consists of eight to 24 weeks of oral DAA therapy. RG-101 is a newly developed therapy, delivered through injection that specifically targets the microNRA in the liver that is essential for HCV to continue to replicate (or stay active) in a person's body. Researchers recently assessed the safety and effectiveness of just a four-week treatment of combining RG-101 with oral DAA therapy in people with HCV genotypes one and four. "Research today focuses on shorter therapies with high efficacy and good safety, explains Mihály Makara, MD; consultant, Hepatology Center of Buda in Budapest, Hungary, and an investigator in the study. "In previous studies, eight weeks seemed to be a limit. RG101 has a pharmacokinetic profile that provides a unique opportunity for shorter treatment." Dr. Makara's team enrolled 79 participants in their study. The participant's average age was around 45 years, and 54 percent of participants were women. Each participant was placed into one of three DAA treatment groups (with consideration for ensuring people with various disease characteristics were evenly distributed): ledipasvir/sofobuvivr (group one), simeprevir (group two) or daclatasivr (group three), and received these medications along with a 2 mg/kg injection of RG-101 at days one and 29 in the study.