- Phase 1 AXAL and durvalumab combination trial shows safety and tolerability in cervical and HPV+ head and neck cancer
- Preclinical data demonstrate synergistic antitumor effects of AXAL combined with a CD137 agonistic antibody, or with an anti- CTLA-4 antibody
- A Phase 1/2 study of durvalumab alone or in combination with AXAL in recurrent/persistent or metastatic cervical or human papillomavirus (HPV)+ squamous cell cancer of the head and neck (HNSCC): Preliminary Phase 1 results (SITC 2016 abstract no. 215354)
- Combination of Listeria-based human papillomavirus (HPV)-E7 cancer vaccine (AXAL) with CD137 agonistic antibody provides an effective immunotherapy for HPV+ tumors in a mouse model (SITC 2016 abstract no. 215321)
The study demonstrated a reprogramming of the tumor microenvironment in favor of antitumor immunity in both of the combination treatment groups. Importantly, there were increased percentages of tumor antigen-specific T cells and mature dendritic cells as well as decreased percentages of regulatory T cells and immunosuppressive macrophages compared to the single-agent treatments. Together, these data show that AXAL in combination with a CD137 agonistic antibody or with a CTLA-4 antagonistic antibody synergize to enhance antitumor immunity.
- AIM2CERV: a randomized phase 3 study of adjuvant AXAL immunotherapy following chemoradiation in patients who have high-risk locally advanced cervical cancer (HRLACC) (SITC 2016 abstract no. 214095)