The Winning Individual for Region FiveManan Shah, a senior from The Harker Upper School in San Jose, CA, won the individual category and a $3,000 scholarship for his project entitled, "Deep Learning Assessment of Tumor Proliferation in Histopathological Images for Categorical and Molecular Breast Cancer Severity and Diagnosis." Manan's work addressed a difficult technical challenge in the field of breast cancer: the rapid, accurate and automated analysis of breast cancer tissue images. He developed a computational model that reviews the tissue images and can help pathologists rapidly and accurately assess the severity of breast cancer tumor growth and spread. His model could help speed diagnostics, improve the molecular understanding of the growth of breast cancer, and help determine more appropriate treatments for each patient. Current systems that pathologists use for grading tumors are inefficient, expensive and laborious. According to the US Centers for Disease Control, breast cancer is the most common cancer in women not counting some types of skin cancer. It's estimated that in the United States one out of eight women and one out of one thousand men will develop breast cancer over the course of their lifetime. "Manan's work is the wave of the future and holds the promise of improving breast cancer diagnosis and making it accessible to many more people, especially those living in areas where there is a scarcity of well-trained pathologists," said competition judge Dr. Pawan Sinha, Professor of Vision and Computational Neuroscience in the Department of Brain and Cognitive Sciences at MIT. "Manan diligently and masterfully applied cutting edge techniques from machine learning and obtained results that define 'state of the art'." Manan is an aspiring computer scientist and applied mathematician and hopes to become a research scientist, using his knowledge of physics, math, and computer science to better predict the behavior of complex systems like cancer development. He has published in the Journal Machine Learning Research. Manan's mentor is Dayong Wang of Beth Israel Deaconess Medical Center's Department of Pathology.
The Winning Team for Region FiveYoshihiro Saito of Ellicott City, MD, and Lauryn Wu of McLean, VA, won the team category and will share a $6,000 scholarship for their project entitled "New Discovery of Large Bulk Band Gap Topological Insulators in Chemically Functionalized Two-Dimensional Compounds." Yoshihiro and Lauryn's computational research could help develop two-dimensional topological insulators (2D TIs) that can be used at room temperature. Currently, 2D TIs are only usable at an extremely low temperature in expensive laboratory settings. Topological insulators, which allow for electrons to move along the surface of a material instead of through the material, have been a major field of study in physics. The 2016 Nobel Prize in Physics was awarded to theoretical physicists for their work in topology. But research in the field has been limited because of the need to cool down topological insulators. 2D TIs usable at room temperature could open up a whole new area of application - such as helping information be transported without degradation. "This research provides a 'play space' for physicists to explore using topological insulators in new and exciting ways -- like building quantum computers and other new electronics," said Michelle Tomasik, a teaching post-doctoral fellow at MIT. "People have theorized a lot of uses for these topological insulators but because we always have to cool them down to use them, it is harder to figure out all of the potential applications for them. I was very impressed with Yoshihiro and Lauryn's depth of knowledge of the field and the materials and they complimented each other very well." Yoshihiro, a sophomore at Marriotts Ridge High School in Marriottsville, MD, was inspired to pursue this area of research because of his passion for physics and the fact that the area of topological insulators is such a growing and exciting field. He has been influenced by many physicists, not only the great Isaac Newton and Einstein, but also contemporary theoretical physicists and astrophysicists, such as Stephen Hawking, Michio Kaku, and Neil DeGrasse Tyson. Yoshihiro has competed in the Science Olympiad and the American Invitational Mathematics Examination (AIME) and he also plays soccer for his high school. Yoshihiro aspires to have a job that involves physics in some way.
Lauryn's love of science and particularly math led her to want to delve deeper into topological insulators with her teammate especially because efficient and productive technology and computers are so essential to everyday life. She has competed in math competitions since elementary school and her proudest accomplishments include being a qualifier in the American Invitational Mathematics Exam (AIME) in sixth grade and serving as Vice President of the National Junior Honor Society. Lauryn plays tennis at a national level and is a top player in the Mid-Atlantic region. Lauryn wants to pursue a career in science or computer programming.The team's mentor is Xuan Luo of the National Graphene Research and Development Center. Regional Finalists The remaining regional finalists each received a $1,000 scholarship. Regional Finalists in the individual category were:
- Jacy Fang , Bergen County Academies, Hackensack, NJ
- Veda Murthy, Lexington High School, Lexington, MA
- Nishita Sinha, Chatham High School, Chatham, NJ
- Albert Yue, Phillips Academy, Andover, MA
- Garyk Brixi, Winston Churchill High School, Potomac, Maryland and Gordan Brixi, Saddlebrook Preparatory School, Wesley Chapel, Florida
- Jang Hun Choi, Jericho Senior High School, Jericho, NY, Matthew Li, Horace Mann School, New York City, NY and Elaine Moon, Peddie School, Hightstown, NJ
- Amir Siraj, Brookline High School, Brookline, MA and Shiva Mudide, Acton Boxborough Regional High School, Acton, MA
- Yi Zhu, Thomas S Wootton High School, Rockville, Maryland and Robert Yang, Montgomery Blair High School, Silver Spring, Maryland
The winners of each regional weekend will be announced at 12 noon (ET) on the following Monday at http://siemensusa.synapticdigital.com/US/Siemens-Foundation . For news and announcements about the Regional Competitions and the National Finals, follow us on Twitter @sfoundation (#SiemensComp) and like us on Facebook at Siemens Foundation.Interviews, video and photos available by visiting http://siemensusa.synapticdigital.com/US/Siemens-Foundation . About the Siemens Foundation The Siemens Foundation has invested more than $90 million in the United States to advance workforce development and education initiatives in science, technology, engineering and math. The Foundation's mission is inspired by the culture of innovation, research and continuous learning that is the hallmark of Siemens' companies. Together, the programs at the Siemens Foundation are helping close the opportunity gap for young people in the U.S. when it comes to STEM careers, and igniting and sustaining today's STEM workforce and tomorrow's scientists and engineers. For further information, visit www.siemens-foundation.org or follow @sfoundation. About Discovery Education Discovery Education is the global leader in standards-based digital content for K-12, transforming teaching and learning with award-winning digital textbooks, multimedia content, professional development, and the largest professional learning community of its kind. Serving 4.5 million educators and over 50 million students, Discovery Education's services are in half of U.S. classrooms, 50 percent of all primary schools in the UK, and more than 50 countries. Discovery Education partners with districts, states and like-minded organizations to captivate students, empower teachers, and transform classrooms with customized solutions that increase academic achievement. Discovery Education is powered by Discovery Communications (NASDAQ: DISCA, DISCB, DISCK), the number one nonfiction media company in the world. Explore the future of education at www.discoveryeducation.com.