JERUSALEM, Israel, Nov. 7, 2016 /PRNewswire/ -- Immunovative Therapies, Ltd., on behalf of it's subsidiary, ImmunoCare, Ltd., today announced the start of a Phase IIb study of CryoVax ®, a next generation immunotherapy cancer vaccine product, for patients with chemotherapy-refractory (third line) metastatic colorectal cancer (mCRC). The trial is being conducted by Banner MD Anderson Medical Center, in Phoenix, AZ, which is partnered with the world renowned University of Texas MD Anderson Cancer Center in Houston, TX, Recruitment in the trial is underway, and the first volunteers have received their initial vaccine doses. Enrollment is expected to be completed by the end of July 2017. About 134,490 people are estimated to be diagnosed with colorectal cancer in the United States each year and about 49,190 of these patients die from the disease. The prognosis for patients with mCRC disease is extremely poor. Intensive research is being conducted to develop treatments for mCRC patients that become refractory to chemotherapy. There have recently been approvals of new agents for chemotherapy-refractory mCRC, but the efficacy of these new agents are modest and often accompanied by some rather significant side-effects. Accordingly, there is still an urgent need for new, effective and low toxic therapies for chemotherapy-refractory mCRC. The success of checkpoint inhibitors in a subset of melanoma and lung cancer patients has elicited much excitement about immunotherapy as a new treatment method for cancer. However, checkpoint inhibition immunotherapy agents have not demonstrated promise in the treatment of mCRC.