Clinical Data from Phase 1 SAD Trials of MYK-461 in Hypertrophic Cardiomyopathy Patients and Healthy VolunteersNew Animal Model Research Advances Understanding of HCM Pathophysiology SOUTH SAN FRANCISCO, Calif., Nov. 04, 2016 (GLOBE NEWSWIRE) -- MyoKardia, Inc. (Nasdaq:MYOK), a clinical stage biopharmaceutical company pioneering a precision medicine approach for the treatment of heritable cardiovascular diseases, today announced presentations at American Heart Association (AHA) Scientific Sessions 2016 highlighting the Company's clinical and animal model research in hypertrophic cardiomyopathy (HCM), novel insights from its SHaRe registry and precision cardiovascular approach, as well as two of MyoKardia's cofounders presenting research in understanding HCM causes and outcomes. AHA Scientific Sessions 2016 will be held Nov. 12-16 in New Orleans. Clinical Data from Phase 1 SAD Trials of MYK-461 in Hypertrophic Cardiomyopathy Data from MyoKardia's two Phase 1 single ascending dose trials of MYK-461 in HCM patients and healthy volunteers will be presented by Martin S. Maron, M.D., Director of the Hypertrophic Cardiomyopathy Center at Tufts Medical Center in Boston. Topline data from the studies were released in July 2016. The studies were designed to establish the safety and tolerability of single oral doses of MYK-461. Secondary objectives included establishing the preliminary pharmacokinetic and pharmacodynamics profiles of MYK-461. Clinical proof of mechanism was observed overall as a dose-dependent reduction in cardiac contractility following single oral doses, in both healthy volunteers and HCM patients. MyoKardia is currently studying MYK-461 in PIONEER-HCM, a Phase 2 open-label single-arm pilot study to evaluate safety, tolerability and efficacy of MYK-461 in subjects with symptomatic, obstructive HCM (oHCM). The U.S. Food and Drug Administration has granted the company Orphan Drug Designation for MYK-461 for the treatment of symptomatic oHCM. The poster presentation, "Obstructive Hypertrophic Cardiomyopathy: Initial Single Ascending Dose Data in Healthy Volunteers and Patients," is part of the "Hypertrophic Cardiomyopathy: New Insights" session. The presentation is on Nov. 15, 10:45 AM to 12:00 PM, in the Science and Technology Hall, Clinical Science Section.