Achillion Announces Upcoming Presentations Of Novel Research Into Complement Biology At The 58th Annual Meeting Of The American Society Of Hematology

NEW HAVEN, Conn., Nov. 03, 2016 (GLOBE NEWSWIRE) -- Achillion Pharmaceuticals, Inc. (Nasdaq:ACHN) today announced that two abstracts have been accepted for poster presentation at the 58th Annual Meeting of the American Society of Hematology (ASH) in San Diego, CA, December 3 - 6, 2016. 

"The data to be presented at ASH expand Achillion's understanding of complement biology and demonstrate the potential advantages of inhibition of factor D in treatment of complement-mediated diseases," said David Apelian, M.D., Ph.D. and Chief Medical Officer of Achillion Pharmaceuticals. "This and other research recently presented by Achillion scientists highlight the potential of our approach as we continue to advance ACH-4471, our first small-molecule factor D inhibitor, through clinical development."

Upcoming Poster Presentations

The poster titled 'Evaluation of bacteria-mediated potential "Bystander" hemolysis of PNH red cells in vitro: No evidence of significant complement classical or lectin pathway-mediated hemolysis induced by microorganisms.' will be presented by Dr. Xuan Yuan from the laboratory of Dr. Robert Brodsky, Johns Hopkins University, a leading PNH expert. Other authors on the poster include: Guangwei Yang; Jane A. Thanassi; Manuel D. Galvan; Steven D. Podos and Mingjun Huang of Achillion, as well as Dr. Brodsky.

This research demonstrated that PNH red cells were not subjected to theoretical "bystander hemolysis" when incubated with the bacteria tested, suggesting no increased risk of pathogen-induced hemolytic breakthrough in PNH patients if treated with a complement alternative pathway (AP) inhibitor.

A second poster titled 'Effect of complement inhibition by anti-C5 (eculizumab) or a small molecule inhibitor of Factor D (ACH-4471) on survival of meningococci in blood from vaccinated adults' will be presented by Dr. Dan M. Granoff, UCSF Benioff Children's Hospital, a world expert on meningococcal infections. Other authors are Monica Konar and Eduardo Lujan of UCSF Benioff Children's Hospital.

Data from this research suggests that vaccination may be more effective in decreasing the risk of meningococcal disease in the presence of an AP inhibitor as compared to a C5 inhibitor.

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