Chimerix Announces Presentation At IDWeek™ Of Detailed 24-Week Results From AdVise Trial Of Brincidofovir For The Treatment Of Adenovirus Infection In Allogeneic Hematopoietic Cell Transplant Recipients
- Results Show Early Virologic Response Associated with Better Overall Survival - DURHAM, N.C., Oct. 27, 2016 (GLOBE NEWSWIRE) -- Chimerix (NASDAQ:CMRX), a biopharmaceutical company developing novel antivirals in areas of high unmet medical need, today announced the presentation of detailed 24-week interim results from the AdVise trial of brincidofovir for the treatment of adenovirus (AdV) infection in allogeneic hematopoietic cell transplant (HCT) recipients at the annual Infectious Diseases conference, IDWeek ™ held October 26-30, 2016 in New Orleans, LA. The results will be presented by Dr. Michael Grimley, Associate Professor, Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital, on Saturday, October 29. "This presentation builds upon the top-line 24-week AdVise results that we announced earlier this year. HCT recipients who were treated with brincidofovir experienced a rapid decline in adenovirus viral load, and overall survival was higher in subjects who had a rapid antiviral response compared with those who did not," said Garrett Nichols, MD, MS, Chief Medical Officer at Chimerix. "Importantly, these data continue to advance our scientific understanding of adenovirus infection, including key risk factors for rapid progression of disease within this complex population; these advances will help us predict which patients are most likely to benefit from brincidofovir as we work to design our next studies." The AdVise trial was an open-label, multicenter study designed to evaluate the efficacy, safety and overall tolerability of brincidofovir for the treatment of AdV infection. In study 304, pediatric and adult patients were placed into one of three cohorts: Cohort A, comprised of allogeneic HCT recipients with asymptomatic or limited AdV infection; Cohort B, comprised of allogeneic HCT recipients with disseminated AdV disease; and Cohort C, comprised of autologous HCT recipients, solid organ transplant recipients and other immunocompromised patients. All subjects were to receive 12 weeks of oral brincidofovir and were followed for 24 weeks after completing treatment. This interim analysis examines outcomes at 24 weeks after the first brincidofovir dose (12 weeks after prescribed dosing duration) and includes 158 patients assigned to Cohorts A (23 adult and 43 pediatric patients) and B (35 adult and 57 pediatric patients).