Alnylam (ALNY) was downgraded to equal-weight from overweight at Barclays. $50 price target. The company has seen multiple pipeline setbacks, Barclays said.
Alnylam was downgraded to neutral from overweight at JPMorgan. $51 price target. Revusiran blow is a big hit to the company's potential growth, JPMorgan said.
Alnylam was downgraded to market perform at Leerink Partners. $40 price target. Revusiran failure adds risk to the company's clinical pipeline, Leerink said.
AutoNation (AN - Get Report) was upgraded to neutral from sell at Goldman Sachs. $49 price target. The valuation is more attractive, as the stock has trailed the market by 15% over the past seven months, Goldman said.
American Express (AXP - Get Report) was downgraded to reduce from neutral at Nomura. $56 price target. The company will likely continue to lose market share and miss revenue expectations, Nomura said.
Imperva (IMPV) was downgraded to neutral from buy at DA Davidson. $55 price target. Despite potential acquisition, there appears to be little upside to valuation, Davidson said.
Tesla (TSLA - Get Report) was downgraded to neutral from buy at Goldman Sachs. $185 price target. Acquisition adds risk to the model and leaves little room for potential production delays, Goldman said.