Among the 47 efficacy-evaluable patients, both objective responses (complete responses (CR) and partial responses (PR)) and stable disease (SD) have been observed. In the Phase 1 experience, Epizyme observed responses that evolved over time from SD to PRs and CRs. At data cutoff, best responses across the four cohorts were as follows:
- DLBCL with GCB subtype and EZH2 mutations (n=5): one PR and two SD;
- DLBCL with GCB subtype and wild-type EZH2 (n=19): two CRs, one PR and six SD;
- DLBCL with non-GCB subtype (n=20): two CRs, four PRs and five SD; and,
- FL with EZH2 mutations (n=3): three PRs.
_____________________________1 Objective response assessed by the Cheson-IWG 2007 criteria 2 Data cut off on May 27, 2016