Waters Corporation (NYSE:WAT) today announced ground-breaking new technology for characterizing glycoproteins. The technology introduction at WCBP 2015, includes the new GlycoWorks™ RapiFluor-MS N-Glycan Kit, the Waters ® ACQUITY UPLC ®, the ACQUITY ® UPLC FLR Detector and the ACQUITY QDa ® detector, and enables scientists to analyze released N-glycans and achieve new levels of speed, sensitivity, simplicity while obtaining previously unattainable structural information.
Supporting Glycan CharacterizationGlycan characterization involves the identification of all of the glycans attached to a glycoprotein no matter how small their concentration and verification of their molecular structure. To do this efficiently requires UPLC-MS-MS instrumentation equal to the challenge. The Waters Glycan Application Solution with UNIFI ®, part of the broader Waters Biopharmaceutical Platform Solution with UNIFI, introduced in 2013, consists of a high-resolution UPLC/QTof-MS system that characterizes and monitors glycans in biopharmaceutical discovery and development labs as well as in the highly-regulated late-stage development and QC organizations. Now, with the enhanced sensitivity made possible by the RapiFluor-MS label, researchers will see a greater optical and mass spectrometric response. This facilitates accurate mass confirmation for low-level peaks and enhances MS/MS glycan fragmentation for definitive glycan assignment. Also being launched are the RapiFluor-MS Dextran Calibration Ladder and Glycan Performance Test Standard, based on pooled IgG, to support benchmarking system performance and conduct Glucose Unit (GU)-based released glycan analysis studies. Waters became the first company to commercialize the GU-based methodology for dextran ladder-based retention time normalization, an approach pioneered by Professor Pauline Rudd of the National Institute for Bioprocessing Research and Training (NIBRT). The GU-based approach makes glycan analysis more robust, allowing UPLC-MS assays to transfer between instruments and laboratories more readily. A new GU glycan database, to facilitate GU and GU+ accurate mass glycan assignments, is in development in collaboration with Professor Rudd and her team at NIBRT, and will be the subject of a joint poster presented at this year's WCBP meeting. For More Information For more information about the GlycoWorks RapiFluor-MS N-Glycan Kit, visit www.waters.com/glycans. About Waters Corporation ( www.waters.com ) For more than 50 years, Waters Corporation has created business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality, consumer products and high-value added chemicals worldwide.
Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.With revenue of $1.99 billion in 2014, Waters is driving scientific discovery and operational excellence for customers worldwide. Waters, GlycoWorks, RapiFluor-MS, ACQUITY, ACQUITY UPLC, UNIFI, QDa and UPLC are trademarks of Waters Corporation.