Today's top-performing billionaire stock picks midday are Ariad Pharmaceuticals, Inc. ( ARIA), Neonode, Inc ( NEON - Get Report) and AutoNation, Inc. ( AN - Get Report). The losers are Freddie Mac / Federal Home Loan Mortgage Corp OTCBB:FMCC, Cree, Inc. ( CREE) and Fannie Mae / Federal National Mortgage Assctn Fnni Me OTCBB:FNMA.

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Fannie Mae

Drug News Spurs Ariad Pharmaceuticals Surge

Ariad Pharmaceuticals, Inc. ( ARIA) surged +7.75% early in this day this Thursday, fueled by news that its lung cancer drug has received breakthrough therapy status from the FDA. In George Soros' investment portfolio since the fourth quarter of 2013, ARIA is still down -16.57% year-to-date.

Neonode, Inc ( NEON - Get Report) got a +6.25% boost on the market today. A developer and licenser of user interfaces and optical multi-touch solutions for user brands, Neonode is a new Q2 investment for George Soros. The company's share price has declined -65.11% YTD, but recent insider buys indicate the tide may be turning.

AutoNation, Inc. ( AN - Get Report) climbed +5.15% after reporting its best September sales since 2007 and predicting even better numbers in the months to come. In the investment portfolios of billionaires Edward Lampert, Steve Mandel and Ray Dalio, AN has climbed +3.62% over the past five days.

Fallout Continues for FMCC, FNMA

Federal Home Loan Mortgage Corp OTCBB:FMCC, better known as Freddie Mac, plunged -22.34% today as the fallout continues from yesterday's court ruling on dividends and liquidation preferences for investors. Adding insult to injury, FMCC also reported that mortgage rates are down for a second straight week. Bruce Berkowitz is one of the billionaire investors taking a big hit with this one.

Cree, Inc. ( CREE) hit midday down -13.57% after announcing preliminary estimates on financial results for its first fiscal quarter and indicating that numbers will be below expectations. In Ray Dalio's investment portfolio since Q3 2013, CREE has declined -49.45% over the past year.

The share price Fannie Mae / Federal National Mortgage Assctn Fnni Me OTCBB:FNMA, fell -13.52% today - also taking a toll on Berkowitz's portfolio. FNMA is down -51.83% YTD and is currently trading near its 52-week low of $1.37.