• Collaboration will identify and evaluate new genomic markers for most common form of non-Hodgkin's lymphoma
  • Results of study will be optimized by CGI to validate and enhance their proprietary genomic panel for DLBCL

RUTHERFORD, N.J., Aug. 25, 2014 (GLOBE NEWSWIRE) -- Cancer Genetics, Inc. (Nasdaq:CGIX) ("CGI" or "The Company"), an emerging leader in DNA-based cancer diagnostics, and Keck Medicine of the University of Southern California (USC) pathologist Imran Siddiqi, M.D., Ph.D., announced today that they have entered into a collaboration to identify and evaluate genomic markers for the prognosis of diffuse large B-cell lymphoma (DLBCL).

DLBCL is the most common aggressive non-Hodgkin lymphoma (NJL), and accounts for approximately 40 percent of all B-cell malignancies. Roughly 20,000 new cases of DLBCL are diagnosed each year in the United States. Despite its prevalence, DLBCL remains difficult to diagnose and prognose. DLBCL has an extremely heterogeneous disease course, and while it exhibits high response rates with standard chemotherapy, durable remission is achieved in only approximately 60 percent of patients. The highest likelihood of relapse is within the first two years, therefore improved prognostication is required to identify those patients most likely to relapse.

Cancer Genetics, Inc. has developed a proprietary genomic test, MatBA®-DLBCL, that offers prognosis of DLBCL based on genomic copy number changes. The collaboration between Siddiqi, assistant professor of clinical pathology at the Keck School of Medicine of USC, and CGI involves the further identification and evaluation of unique genomic copy number changes that can serve as additional prognostic markers in DLBCL. Genomic aberrations that significantly correlate with patient prognosis will be further analyzed and added to the panel of genomic aberrations that CGI has previously identified as having prognostic values in DLBCL. This collaboration will enhance the value of the proprietary MatBA®-DLBCL assay currently offered by CGI.

"Patients with aggressive B-cell lymphomas can have heterogeneous presentations, and it is often difficult to predict their responses to standard therapies," said Siddiqi. "We have an urgent clinical need for practical, robust assays that allow reproducible molecular subclassification and prognostic stratification of these diseases. Through this collaboration with CGI, we hope to evaluate the clinical utility of their genome-wide panel of aberrations in our cohort of DLBCL patients. In a broader sense, our studies may provide biological insights for this disease in diverse patient populations."

A number of gains have recently been made in the treatment of B-cell malignancies, including the July 23 Food and Drug Administration approval of Gilead's Zydelig® for chronic lymphocytic leukemia, follicular lymphoma, and small lymphocytic lymphoma. There are currently more than 600 clinical trials in phases II and III investigating drugs for DLBCL and some 1,500 for B-cell malignancies. In addition to offering improved diagnosis and prognostic information for patients with non-Hodgkin's lymphomas and leukemias, CGI's proprietary tests allow biotech and biopharma customers to more efficiently stratify and monitor patients enrolled in these clinical trials.

Cancer Genetics, Inc. and Siddiqi recently completed another collaborative study on CD23+ diffuse nodal follicular lymphoma. Preliminary results of this study will be reported in an oral presentation in the 17 th Meeting of the European Association for Hematopathology, to be held in Istanbul, October 17-22, 2014. Siddiqi has no financial ties to Cancer Genetics Inc.

About Cancer Genetics

Cancer Genetics Inc. (Nasdaq:CGIX) is an emerging leader in DNA-based cancer diagnostics, servicing some of the most prestigious medical institutions in the world. Our tests target cancers that are difficult to diagnose and predict treatment outcomes. These cancers include hematological, urogenital, and HPV-associated cancers. We also offer a comprehensive range of non-proprietary oncology-focused tests and laboratory services that provide critical genomic information to healthcare professionals, as well as biopharma and biotech companies. Our state-of-the-art reference lab is focused entirely on maintaining clinical excellence and is both CLIA certified and CAP accredited and has licensure from several states including New York State. We have established strong research collaborations with major cancer centers such as Memorial Sloan-Kettering, The Cleveland Clinic, Mayo Clinic and the National Cancer Institute.

For further information, please see http://www.cancergenetics.com.

Forward Looking Statements: This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements pertaining to future financial and/or operating results, future growth in research, technology, clinical development and potential opportunities for Cancer Genetics, Inc. products and services, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to, statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, risks of cancellation of customer contracts or discontinuance of trials, risks that the transaction will not close or, if it closes, will not realize the currently anticipated benefits, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, maintenance of intellectual property rights and other risks discussed in the Company's Form 10-K for the year ended December 31, 2013 and 10-Q for the quarter ended March 31, 2014 along with other filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof. Cancer Genetics disclaims any obligation to update these forward-looking statements.
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