Agilent Technologies, Inc. (NYSE: A) today introduced the first in a series of novel synthetic biology solutions for rational mutagenesis. The QuikChange HT Protein Engineering System is a site-directed mutagenesis solution that creates libraries of rationally designed protein variants. The screening of these variants allows scientists to quickly understand protein structure and its effects on function while looking for enhanced forms, all in one experiment. QuikChange HT enables single amino acid scanning, site saturation scanning and targeted combinatorial mutagenesis at a fraction of the cost currently offered by other synthetic gene vendors. “Now in less than twenty-four hours, researchers can define and customize mutations for every amino acid in a whole protein or domain,” said Victor Fung, senior director of Agilent’s Diagnostics and Genomics Division. “With access to free mutagenesis software, workspace scientists can design large mutagenic libraries of up to 120,000 defined variants, with unparalleled speed, accuracy and scope.” This new technology combines the synthesis accuracy of Oligo Library Synthesis with the benefits of QuickChange to provide researchers the most accurate and efficient targeted codon mutagenesis platform available today. “QuikChange HT is a most cost-effective protein engineering system with the ability to create rational variant libraries of up to 120,000 recombinant mutants,” said Fung. “It’s more cost effective to synthesize only the DNA needed to create the mutation, rather than making the entire gene. All this requires less than six hours of hands-on time and just one day to complete.” For more information about QuikChange HT, visit www.agilent.com/genomics/QuikChangeHT About Agilent Technologies Agilent Technologies Inc. (NYSE: A) is the world’s premier measurement company and a technology leader in chemical analysis, life sciences, diagnostics, electronics and communications. The company’s 20,600 employees serve customers in more than 100 countries. Agilent had revenues of $6.8 billion in fiscal 2013. Information about Agilent is available at www.agilent.com. On Sept. 19, 2013, Agilent announced plans to separate into two publicly traded companies through a tax-free spinoff of its electronic measurement business. The new company is named Keysight Technologies, Inc. The separation is expected to be completed in early November 2014.
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