bluebird bio, Inc. (Nasdaq: BLUE), a clinical-stage company committed to developing potentially transformative gene therapies for severe genetic and orphan diseases, today reported financial results and operational highlights for the fiscal year ended December 31, 2013. At fiscal year end bluebird bio held $206.3 million in cash and cash equivalents. Pipeline Update and 2013 Highlights Lenti-D (Childhood Cerebral Adrenoleukodystrophy)
- Starbeam Study: In October 2013, the first patient in the phase 2/3 Starbeam (ALD-102) study was transplanted with bluebird’s Lenti-D product candidate. This study is planned to enroll 15 patients with childhood cerebral adrenoleukodystrophy with at least 12 patients being evaluable. The primary endpoint of the study is the percentage of patients that do not develop a major functional disability at 24 months after their transplant. We anticipate completing enrollment in 2015.
- HGB-205 Study: In November 2013, the first patient in the phase 1/2 HGB-205 study was transplanted with bluebird’s LentiGlobin product candidate. The HGB-205 study is planned to enroll 7 patients with beta thalassemia major or sickle cell disease at a single site in Paris, France. We anticipate that the first sickle cell patient will be transplanted in this study in 2014.
- Northstar Study: The Northstar (HGB-204) study is a US phase 1/2 study that is planned to enroll 15 patients with thalassemia major. The first patient in this study is expected to be transplanted in early 2014.
- bluebird bio plans to present preliminary data from the HGB-205 and Northstar studies in late 2014.
- Sickle Cell Disease Study: bluebird bio anticipates filing an IND in mid-2014 to start a study with LentiGlobin in patients with sickle cell disease.
Net cash provided by operating activities during the year ended December 31, 2013 was $43.5 million. bluebird bio held $206.3 million in cash and cash equivalents as of December 31, 2013.Total operating expenses for the year ended December 31, 2013 were $45.1 million as compared to $24.1 million for the year ended December 31, 2012. bluebird bio reported a net loss of $25.3 million, or $2.02 per share, for the year ended December 31, 2013, as compared to net loss applicable to common stockholders of $3.6 million, or $13.79 per share, for the year ended December 31, 2012. 2013 Business Highlights:-- In December, bluebird bio joined the NASDAQ Biotechnology Index and in October, joined the Russell 2000 Index-- In December, the Company announced that the first patient had been transplanted in the HGB-205 study for beta thalassemia major and sickle cell disease-- In October, the Company announced that the first patient had been transplanted in the Starbeam (ALD-102) study for childhood cerebral adrenoleukodystrophy-- In August, the Company was selected as a 2014 Technology Pioneer by the World Economic Forum-- In June, the Company completed an initial public offering raising approximately $104.9 million, net of underwriting discounts and commissions and estimated offering expenses-- In May, the Company strengthened its Board of Directors with two additions, Wendy Dixon, Ph.D. and David Schenkein, M.D.-- In March, the Company signed a multi-year collaboration with Celgene Corporation focused on the development of chimeric antigen receptor-modified T cells (CAR-T) for the treatment of cancer. "bluebird bio has had a tremendous year," stated Nick Leschly, chief bluebird. "In 2013 we transplanted the first patients in our phase 2/3 Starbeam study for CCALD and our phase 1/2 HGB-205 study for beta thalassemia and sickle cell disease. This was a considerable accomplishment for all those involved in these studies. Earlier in the year, we leveraged our lentiviral platform, signing a multi-year collaboration with Celgene in the exciting area of CAR T for oncology, which strengthened our balance sheet and further validated our lentiviral platform. In June, we completed a successful IPO, setting the stage for the next evolution in the bluebird story. We look forward to another productive year in 2014.”
Calendar Year 2014 Anticipated Milestones:-- First patient transplanted in HGB-204 thalassemia major study in early 2014-- File an IND for sickle cell disease study in mid-2014-- Transplant first sickle cell patient(s) in 2014-- Present preliminary thalassemia data from HGB-205 and Northstar studies in late 2014.About bluebird bio, Inc. bluebird bio is a clinical-stage company committed to developing potentially transformative gene therapies for severe genetic and orphan diseases. bluebird bio has two clinical-stage programs in development. The most advanced product candidate, Lenti-D, is in a recently-initiated phase 2/3 study for the treatment of childhood cerebral adrenoleukodystrophy (CCALD), a rare, hereditary neurological disorder affecting young boys. The next most advanced product candidate, LentiGlobin, is currently in a phase 1/2 study in France for the treatment of beta-thalassemia major and severe sickle cell disease. A second phase 1/2 study with LentiGlobin in the United States has been initiated for the treatment of beta-thalassemia major. bluebird bio also has an early-stage chimeric antigen receptor-modified T cell (CAR-T) program for oncology in partnership with Celgene Corporation. bluebird bio has operations in Cambridge, Massachusetts and Paris, France. For more information, please visit www.bluebirdbio.com Forward-Looking Statements This release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding the advancement of, timing of data announcement for, and anticipated milestones related to the Company’s clinical studies. Any forward-looking statements in this press release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk of cessation or delay of any of the ongoing or planned clinical studies and/or our development of our product candidates, the risk of a delay in the enrollment of patients in the Company’s clinical studies, the risk that the results of previously conducted studies involving similar product candidates will not be repeated or observed in ongoing or future studies involving current product candidates, the risk that our collaboration with Celgene will not continue or will not be successful, and the risk that any one or more of our product candidates will not be successfully developed and commercialized. For a discussion of other risks and uncertainties, and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, see the section entitled "Risk Factors" in our most recent annual report on Form 10-K, as well as discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and bluebird bio undertakes no duty to update this information unless required by law.
|bluebird bio, Inc.|
|Consolidated Statements of Operations and Comprehensive Loss|
|(in thousands, except per share data)|
|Year ended December 31,|
|Research and license fees||389||340|
|Research and development||31,002||17,210|
|General and administrative||14,126||6,846|
|Total operating expenses||45,128||24,056|
|Loss from operations||(24,947||)||(23,716||)|
|Other income (expense), net:|
|Foreign currency gains (losses)||37||13|
|Re-measurement of warrants||(440||)||28|
|Other income (expense), net||(374||)||46|
|Net loss applicable to common stockholders||$||(25,321||)||$||(3,613||)|
|Net loss per share applicable to common|
|stockholders - basic and diluted:||$||(2.02||)||$||(13.79||)|
|Weighted-average number of common shares used|
|in net loss per share applicable to common|
|stockholders - basic and diluted:||12,555||262|
|bluebird bio, Inc.|
|Consolidated Balance Sheets|
|(in thousands, except per share data)|
|December 31,||December 31,|
|Cash and cash equivalents||$||206,279||$||67,011|
|Deferred tax assets||693||-|
|Prepaid expenses and other current assets||5,015||773|
|Total current assets||211,987||67,784|
|Property and equipment, net||10,920||1,288|
|Restricted cash and other non-current assets||1,483||250|
|Liabilities, convertible preferred stock, and stockholders' equity (deficit)|
|Accrued expenses and other current liabilities||5,175||2,115|
|Deferred revenue, current portion||25,340||340|
|Total current liabilities||34,874||4,628|
|Deferred rent, net of current portion||6,740||46|
|Deferred revenue, net of current portion||30,208||340|
|Deferred tax liabilities||693||-|
|Other non-current liabilities||208||-|
|Convertible preferred stock||-||119,840|
|Total stockholders' equity (deficit)||151,667||(55,747||)|
|Total liabilities, convertible preferred stock and stockholders' equity (deficit)||$||224,390||$||69,322|