DELAFIELD, Wis. ( Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.>>5 Stocks Set to Soar on Bullish Earnings Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors." Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock. >>5 Rocket Stocks Worth Buying This Week With that in mind, let's take a look at several stocks rising on unusual volume today. Cempra Cempra ( CEMP) is a clinical-stage pharmaceutical company which is developing antibiotics to meet critical unmet medical needs in the treatment of bacterial infectious diseases. This stock closed up 3.6% to $13.50 in Monday's trading session. Monday's Volume: 387,000
Three-Month Average Volume: 162,828
Volume % Change: 125% From a technical perspective, CEMP spiked higher here into new all-time high territory with above-average volume. This stock has been uptrending strong for the last six months, with shares moving higher from its low of $6.95 to its intraday high of $13.63. During that uptrend, shares of CEMP have been making mostly higher lows and higher highs, which is bullish technical price action. Market players should now look for a continuation move higher in the short-term if CEMP can manage to clear Monday's high of $13.63 with strong volume. Traders should now look for long-biased trades in CEMP as long as it's trending above some near-term support at $12.50 and then once it sustains a move or close above Monday's high of $13.63 with volume that hits near or above 162,828 shares. If we get that move soon, then CEMP will set up to enter new all-time high territory, which is bullish technical price action. Some possible upside targets off that move are $17 to $18.