>>5 Big Trades for Year-End Gains Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade. Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success. >>5 Stocks Insiders Love Right Now With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside today.Prosensa Holding Prosensa Holding ( RNA) is engaged in the discovery and development of RNA-modulating therapeutics for the treatment of rare genetic disorders. This stock closed up 17.6% to $4.81 in Thursday's trading session. Thursday's Range: $4.11-$4.94 52-Week Range: $3.43-$34.55 Thursday's Volume: 456,000 Three-Month Average Volume: 671,928 From a technical perspective, RNA exploded higher here right above some near-term support at $4.03 and back above its 50-day moving average of $4.40 with decent upside volume. This move is quickly pushing shares of RNA within range of triggering a major breakout trade. That trade will hit if RNA manages to take out Thursday's high of $4.94 and then once it takes out some more near-term overhead resistance at $5.35 with high volume. Traders should now look for long-biased trades in RNA as long as it's trending above some key near-term support at $4.03, and then once it sustains a move or close above those breakout levels with volume that hits near or above 671,928 shares. If that breakout hits soon, then RNA will set up to re-test or possibly take out its next major overhead resistance levels at $6 to $7.30.