Anacor PharmaceuticalsAnacor Pharmaceuticals ( ANAC) is engaged in the discovery, development and commercialization of novel small molecule therapeutics derived from its novel boron chemistry platform. This stock closed up 12.9% at $14.21 in Wednesday's trading session. Wednesday's Volume: 668,000 Three-Month Average Volume: 396,517 Volume % Change: 145% >>5 Stocks Poised for Breakouts From a technical perspective, ANAC skyrocketed higher here right above its 50-day moving average of $11.63 and into breakout territory above some resistance at $13.32 with strong upside volume. This move is quickly pushing shares of ANAC within range of triggering another big breakout trade. That trade will ht if ANAC manages to take out Wednesday's high of $14.24 to its 52-week high at $14.39 with high volume. Traders should now look for long-biased trades in ANAC as long as it's trending above $13 or $12 and then once it sustains a move or close above those breakout levels with volume that hits near or above 396,517 shares. If that breakout hits soon, then ANAC will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are $18 to $20. Health Management AssociatesHealth Management Associates ( HMA) provides health care services to patients in owned and leased facilities located mainly in non-urban communities in the Southeastern and Southwestern U.S. This stock closed up 5.6% at $13.24 in Wednesday's trading session. Wednesday's Volume: 30.33 million Three-Month Average Volume: 3.81 million Volume % Change: 376% From a technical perspective, HMA gapped higher here back above both its 50-day and 200-day moving averages with monster upside volume. This move is quickly pushing shares of HMA within range of triggering a major breakout trade. That trade will hit if HMA manages to take out Wednesday's high of $13.35 to its gap down day high from late July at $13.66 with high volume. Traders should now look for long-biased trades in HMA as long as it's trending above Wednesday's low at $13.09 or above its 200-day at $12.79 and then once it sustains a move or close above those breakout levels with volume that's near or above 3.81 million shares. If that breakout hits soon, then HMA will set up to re-fill some of its previous gap down zone from July that started near $17.