Flemming Ornskov, MD, Chief Executive Officer and Graham Hetherington, Chief Financial Officer will host the investor and analyst conference call today (Monday 11 November 2013) at 08:30am GMT/ 03:30am EST.The details of the conference call are as follows: UK dial in: 08082370030 or 02031394830 US dial in: 1 866 928 7517 or 1 718 873 9077 International Access Numbers: Click here Password/Conf ID: 30849732# Live Webcast: Register here for the live webcast Replay: A replay of the presentation will be available for two weeks by phone and by webcast for three months. The details of the replay are below: Playback number: +44 (0)20 3426 2807 Playback UK toll free number: 0808 237 0026 Password/Conf ID: 643242# Webcast replay Click here NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Shire's strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs. Shire provides treatments in Neuroscience, Rare Diseases, Gastrointestinal, Internal Medicine and Regenerative Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas. http://www.shire.com About Hereditary Angioedema HAE is a rare genetic disease caused by low levels or a dysfunction of C1 esterase inhibitor (C1-INH). Reduced C1-INH activity can lead to elevated plasma levels of bradykinin, which is thought to be responsible for HAE symptoms. HAE is characterized by recurrent sudden attacks of edema (swelling) of the skin (hands, arms, feet, legs, thighs, face, genitals) or the mucous membranes (gastrointestinal tract, larynx or voicebox). The swelling can be disfiguring and painful, especially in case of abdominal attacks. Laryngeal attacks are potentially life-threatening due to the risk of suffocation. Unlike angioedema caused by allergic reactions, signs and symptoms such as hives and itching do not occur in HAE. Signs and symptoms of HAE do not respond to standard treatments for allergic angioedema such as epinephrine, corticosteroids, and antihistamines.