1. BioSpecifics Technologies Corp. ( BSTC): Involves in the development of an injectable collagenase for various indications.Market cap at $122.84M, most recent closing price at $19.39. Over the last six months, insiders were net buyers of 178,265 shares, which represents about 4.54% of the company's 3.93M share float. Since October 7 th, BioSpecifics Technologies has returned 0.73%, while fellow biotechnology companies Gilead Sciences Inc. (GILD) and Amgen Inc. (AMGN) have returned 9.05% and 2.82%, respectively. In the pipeline: On October 23 rd, BioSpecifics Technologies announced the start of its Phase 2a study for cellulite treatment. XIAFLEX, the company's injectable collagenase that is approved for treating Dupuytren's contracture in the US, is being used in the study, and results are expected to be released in the first quarter of 2015. Between 70-90% of women have cellulite (it's quite rare in men), and US consumers spend millions of dollars annually trying to get rid of it. The Food and Drug Administration (FDA) has yet to approve any pharmaceutical treatments for cellulite. 2. MannKind Corp. ( MNKD): Focuses on the discovery, development, and commercialization of therapeutic products for diabetes and cancer. Market cap at $1.33B, most recent closing price at $4.68. Over the last six months, insiders were net buyers of 39,896,322 shares, which represents about 24.14% of the company's 165.29M share float. MannKind has returned -7.71% over the last month. Its performance surpasses that of competitors Threshold Pharmaceuticals Inc. (THLD) and Merrimack Pharmaceuticals, Inc. (MACK), but falls short of Amgen's 2.82% and BioSpecifics Technologies' 0.73%. In the pipeline: At the end of October, the FDA acknowledged Mannkind's resubmitted new drug application for Afrezza, the company's highly anticipated inhalable insulin treatment. The FDA scheduled Afrezza's Prescription Drug User Fee Act (PDUFA) date for April 15, which is when Mannkind will have to pay fees for its New Drug Application. COO Hakan Edstrom viewed the PDUFA date as a positive development, stating "the FDA's two-week action to set the PDUFA date is the agency's regular positive response at this point in today's regulatory process." Presently 347 million people worldwide suffer from diabetes, and that number will only grow as the disease likely becomes the 7th leading cause of death by 2030. Furthermore, according to Research and Markets, the global diabetes drug industry is expected to swell to $56.9 billion in 2018.