DELAFIELD, Wis. ( Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.>>5 Stocks Insiders Love Right Now Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors." Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock. >>5 Rocket Stocks to Buy Now With that in mind, let's take a look at several stocks rising on unusual volume today. Amag Pharmaceuticals Amag Pharmaceuticals ( AMAG) is a specialty pharmaceutical company focused on the development and commercialization of Feraheme injection for IV use to treat iron deficiency anemia. This stock closed up 7.1% to $22.98 in Wednesday's trading session. Wednesday's Volume: 413,000
Three-Month Average Volume: 96,146
Volume % Change: 286% >>5 Stocks Under $10 to Trade for Breakouts From a technical perspective, AMAG bounced sharply higher here right off its 200-day moving average of $21.24 with heavy upside volume. This move briefly pushed shares of AMAG above its 50-day moving average of $22.98, before it closed right at that level. Traders should now look for long-biased trades in AMAG as long as it's trending above its 200-day at $21.24 and then once it sustains a move or close above Wednesday's high of $23.75 with volume that hits near or above 96,146 shares. If we get that move soon, then AMAG will set up to re-test or possibly take out its next major overhead resistance levels at $25.50 to its 52-week high at $27. Kythera Biopharmaceuticals Kythera Biopharmaceuticals ( KYTH) is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel prescription products for the aesthetic medicine market. This stock closed up 1.1% at $43.69 in Wednesday's trading session.