BALTIMORE ( Stockpickr) - Don't let your guard down. The S&P 500 may be poking holes in new all time highs and the nonsense on Capitol Hill may even be resolved, but that doesn't meant that you should keep hanging onto everything in your portfolio. >>5 Rocket Stocks to Buy Now That's because even the biggest, "safest" blue-chips could be toxic to your performance in the final quarter of this year. There's no question that the big indices are still in bull mode, but it's worth noting that the Dow Jones Industrial Average looks materially weaker than the S&P right now. The big names that tend to dominate the Dow are starting to show some cracks -- well, some of them are, anyway. That's why we're taking a closer look at five "toxic" stocks you should be selling in October. To be fair, the companies I'm talking about today aren't exactly "junk." By that, I mean they're not next up in line at bankruptcy court. But that's frankly irrelevant; from a technical analysis standpoint, they're some of the worst positioned names out there right now. For that reason, fundamental investors need to decide how long they're willing to take the pain if they want to hold onto these firms this summer. And for investors looking to buy one of these positions, it makes sense to wait for more favorable technical conditions (and a lower share price) before piling in. >>The Pros Hate These 5 Stocks -- Should You? For the unfamiliar, technical analysis is a way for investors to quantify qualitative factors, such as investor psychology, based on a stock's price action and trends. Once the domain of cloistered trading teams on Wall Street, technicals can help top traders make consistently profitable trades and can aid fundamental investors in better planning their stock execution. So, without further ado, let's take a look at five toxic stocks you should be unloading.