DELAFIELD, Wis. ( Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.>>5 Stocks Poised for Breakouts Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors." Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock. >>5 Stocks Under $10 Set to Soar With that in mind, let's take a look at several stocks rising on unusual volume today. Rockwell Medical Rockwell Medical ( RMTI) is a biopharmaceutical company targeting end-stage renal disease and chronic kidney disease with innovative products and services for the treatment of iron deficiency, secondary hyperparathyroidism and hemodialysis. This stock closed up 5.8% at $11.40 in Monday's trading session. Monday's Volume: 11.19 million
Three-Month Average Volume: 2.22 million
Volume % Change: 415% >>5 Stocks With Big Insider Buying From a technical perspective, RMTI ripped higher here and entered new 52-week-high territory with heavy upside volume. Shares of RMTI flirted with some key overhead resistance on Monday at $11.80, before closing below that level at $11.40. Traders should now look for long-biased trades in RMTI as long as it's trending above $10.50 or $10 and then once it sustains a move or close above Monday's intraday high of $12.25 with volume that hits near or above 2.22 million shares. If we get that move soon, then RMTI will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that move are its next major overhead resistance levels at $13 to $15, or even $16. American Pacific American Pacific ( APFC) is a custom manufacturer of fine chemicals, specialty chemicals and propulsion products. This stock closed up 4.2% at $54.76 in Monday's trading session.