DELAFIELD, Wis. ( Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.>>5 Stocks Insiders Love Right Now Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors." Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock. >>5 Stocks Set to Soar on Bullish Earnings With that in mind, let's take a look at several stocks rising on unusual volume today. Vanda Pharmaceuticals Vanda Pharmaceuticals ( VNDA) is a biopharmaceutical company focusing on the development and commercialization of clinical-stage drug candidates for central nervous system disorders. This stock closed up 9.1% to $13.03 in Wednesday's trading session. Wednesday's Volume: 2.17 million
Three-Month Average Volume: 1.01 million
Volume % Change: 145% >>5 Biotech Stocks Under $10 to Watch From a technical perspective, VNDA ripped higher here and broke out above some near-term overhead resistance levels at $12.34 to $12.66 with heavy upside volume. This move is quickly pushing shares of VNDA within range of triggering another big breakout trade. That trade will hit if VNDA manages to take out Wednesday's high at $13.11 to its 52-week high at $13.30 with high volume. Traders should now look for long-biased trades in VNDA as long as it's trending above that first breakout level at $12.34 or above support at $12 and then once it sustains a move or close above those breakout levels with volume that hits near or above 1.01 million shares. If that breakout hits soon, then VNDA will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that move are $15 to $17.