earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade. Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success. With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside today. Echo Therapeutics ( ECTE) This company is a transdermal medical device company with skin permeation technology. This stock closed up 5.4% to $2.88 in Tuesday's trading session. Tuesday's Range: $2.75-$2.99 52-Week Range: $1.80-$18.90 Tuesday's Volume: 140,000 Three-Month Average Volume: 217,495 From a technical perspective, ECTE bounced sharply higher here right above its 50-day moving average at $2.64 with decent upside volume. This move is quickly pushing shares of ECTE within range of triggering a big breakout trade. That trade will hit if ECTE manages to clear Tuesday's intraday high of $2.99 and then once it takes out more resistance at $3.30 with high volume. Traders should now look for long-biased trades in ECTE as long as it's trending above its 50-day at $2.64 or above more near-term support at $2.50, and then once it sustains a move or close above those breakout levels with volume that hits near or above 217,495 shares. If that breakout triggers soon, then ECTE will set up to re-test or possibly take out its next major overhead resistance levels at $4 to $4.50.