Traders should now look for long-biased trades in ISIS as long as it's trending above Monday's low of $29.85 or above its 50-day at $28.37 and then once it sustains a move or close above those breakout levels with volume that hits near or above 1.50 million shares. If that breakout triggers soon, then ISIS will set up to enter new 52-week-high territory above $34.31, which is bullish technical price action. Some possible upside targets off that breakout are $40 to $43. To see more stocks rising on unusual volume, check out the Stocks Rising on Unusual Volume portfolio on Stockpickr. -- Written by Roberto Pedone in Delafield, Wis.