DELAFIELD, Wis. ( Stockpickr) -- Trading stocks that trigger major breakouts can lead to massive profits. Once a stock trends to a new high, or takes out a prior overhead resistance point, then it's free to find new buyers and momentum players that can ultimately push the stock significantly higher.>>5 High-Yield Tech Stocks Poised to Boost Dividends One example of a successful breakout trade I flagged recently was development-stage biopharmaceutical player Biodel ( BIOD), which I featured in July 18's " 5 Stocks Under $10 Set to Soar" at around $4.60 a share. I mentioned in that piece that shares of BIOD had been trending sideways, with the stock moving between $3.93 on the downside and $5.11 on the upside. The stock was just starting to break out above some near-term overhead resistance at $4.46 a share, and it was quickly moving within range of triggering a major breakout trade above the upper-end of its recent range at $4.46 to $5.11 a share. Guess what happened? Shares of BIOD didn't wait long to trigger that move, since the stock started to break out on July 29 with heavy upside volume. After shares of BIOD cleared resistance at $4.46 to $5.11 a share with strong volume, then the stock quickly tagged its recent 52.week high at $6.08 a share. That represents a gain of just over 30% for anyone who loaded up on BIOD once it triggered that technical breakout. You can see here how powerful trading breakouts can be, and the key is always to follow price and volume. >>5 Stocks Under $10 Set to Soar Breakout candidates are something that I tweet about on a daily basis. I frequently tweet out high-probability setups, breakout plays and stocks that are acting technically bullish. These are the stocks that often go on to make monster moves to the upside. What's great about breakout trading is that you focus on trend, price and volume. You don't have to concern yourself with anything else. The charts do all the talking. Trading breakouts is not a new game on Wall Street. This strategy has been mastered by legendary traders such as William O'Neal, Stan Weinstein and Nicolas Darvas. These pros know that once a stock starts to break out above past resistance levels, and hold above those breakout prices, then it can easily trend significantly higher. >>5 Stocks Warren Buffett Is Buying in 2013 With that in mind, here's a look at five stocks that are setting up to break out and trade higher from current levels.