Editor's Note: Any reference to TheStreet Ratings and its underlying recommendation does not reflect the opinion of TheStreet, Inc. or any of its contributors including Jim Cramer or Stephanie Link. All three major indices are trading up today with the Dow Jones Industrial Average ( ^DJI) trading up 20 points (0.1%) at 14,984 as of Friday, Aug. 23, 2013, 12:50 PM ET. The NYSE advances/declines ratio sits at 1,794 issues advancing vs. 1,149 declining with 104 unchanged. The Drugs industry currently sits down 0.2% versus the S&P 500, which is up 0.2%. On the negative front, top decliners within the industry include Chemocentryx ( CCXI), down 33.8%, and Allergan ( AGN), down 0.9%. TheStreet would like to highlight 5 stocks pushing the industry lower today: 5. Shire ( SHPG) is one of the companies pushing the Drugs industry lower today. As of noon trading, Shire is down $0.66 (-0.6%) to $113.32 on heavy volume. Thus far, 293,022 shares of Shire exchanged hands as compared to its average daily volume of 349,100 shares. The stock has ranged in price between $112.88-$113.54 after having opened the day at $113.30 as compared to the previous trading day's close of $113.99. Shire plc, a specialty biopharmaceutical company, engages in the research and development, manufacture, sale, and distribution of pharmaceutical products. It operates in three segments: Specialty Pharmaceuticals (SP), Human Genetic Therapies (HGT), and Regenerative Medicine (RM). Shire has a market cap of $21.4 billion and is part of the health care sector. Shares are up 23.7% year to date as of the close of trading on Thursday. Currently there are 9 analysts that rate Shire a buy, no analysts rate it a sell, and 3 rate it a hold. TheStreet Ratings rates Shire as a buy. The company's strengths can be seen in multiple areas, such as its revenue growth, largely solid financial position with reasonable debt levels by most measures, increase in stock price during the past year, growth in earnings per share and expanding profit margins. We feel these strengths outweigh the fact that the company shows weak operating cash flow. Get the full Shire Ratings Report now. STOCKS TO BUY: TheStreet Quant Ratings has identified a handful of stocks that can potentially TRIPLE in the next 12-months. Learn more.